No dose–no poison

Pessimism is no poison.

Dee Jones is 35 years old, married, and the mother of three children, all younger than15 years of age. She had been healthy all of her life before she presented with a 2-week history of abdominal discomfort and anorexia. Evaluation revealed moderate jaundice, an enlarged liver, and abnormal liver function tests. An image of the abdomen showed a pancreatic mass and widespread metastatic disease ...

Skeletal muscle lipid flux: running water carries no poison.

Lipids are the most abundant organic constituents in many humans. The rise in obesity prevalence has prompted a need for a more refined understanding of the effects of lipid molecules on cell physiology. In skeletal muscle, deposition of lipids can be associated with insulin resistance that contributes to the development of diabetes. Here, we review the evidence that muscle cells are equipped w...

Poison ivy, poison oak, and poison sumac.

Poison Romance and Poison Mysteries

Searching for a Poison in a Poison

chlorinated biphenyl (PC8I mixtures had been described previously. High mortality, liver damage, and edema were associated with only two of the three PCB5. Using column and gas chromatography, several compounds were identified in the diethylether fracdon of these two PCBs. A chick embryo assay confirmed the high toxicity of this fraction. Mass spectremetric and microcoulometric analyses indicat...